Molecular Pathology

The molecular pathology laboratory was created to mainly support the Division of Hematopathology.  The four hematopathologists within Clin-Path Associates, PLC, oversee this area and sign out all reports from the molecular laboratory.  This area consists of two distinct testing modalities, flow cytometry and fluorescence in situ hybridization.

Flow cytometry detects specific surface and some cytoplasmic proteins which are used in the diagnosis of lymphoma, acute and chronic leukemia’s, and paroxysmal nocturnal hemoglobinuria.  This testing is highly sensitive and specific.  We perform these tests on bone marrow, lymph nodes, cytological fluids, and peripheral blood.  The results are available within 24 hours and same day testing can be arranged.

Fluorescence in situ hybridization (FISH) analysis consists of fluorescent tagged probes which attach to specific abnormal gene loci which are associated with specific hematopoietic diseases.  These probes are also highly sensitive and specific and can confirm a hematopoietic disease which is difficult to diagnose with morphology alone.  Although almost all the probes are for hematopoietic diseases, we also perform fluorescence in situ hybridization analysis for Her2/neu (a breast cancer marker). Fluorescence in situ hybridization analysis results are usually available within 48-72 hours.  We offer a rapid same day analysis for the acute promyelocytic leukemia (PML/RARA) and chronic myelogenous leukemia (BCR/ABL).

Again, the hematopathologists are immediately available for consultation for flow cytometry or fluorescence in situ hybridization results.

  • James D. Cason, M.D.
  • Yuan Lin, M.D., Ph.D.
  • Chalengpoj “Charlie” Sthapanachai, M.D.
  • Philip R. Zollars, M.D.
© Copyright Clin-Path Associates, PLC - Theme by Pexeto